Επισημαίνω:
Core Equipment Empowering Pharmaceutical R&D and Small-Batch Production – JL-100II Soft Capsule Machine
Pharmaceutical R&D institutions and small-to-medium-sized soft capsule enterprises often face two core pain points: severe loss of high-value materials due to insufficient equipment precision during R&D, and low qualification rates stemming from inadequate compliance and stability in small-batch production. With over a decade of deep expertise in the industry, Wuxi Jangli Machinery Co., Ltd. has launched the purpose-built JL-100II Soft Capsule Machine. Boasting core advantages of precise metering, stable operation, and compliance compatibility, it connects the entire chain from "R&D pilot-scale testing to batch production" and delivers cost-effective solutions.
Unlike the "small-scale simplified versions" of traditional mass-production equipment, the JL-100II focuses on the core needs of "rapid verification of multiple formulas" and "low-cost compliant batch production." Through 12 key structural optimizations, it upgrades core technologies including mold replacement, film forming, and filling precision, breaking the transformation bottleneck from "laboratory formulas to small-batch production." It serves as both a "data guarantee device" for R&D institutions and a "reliable tool for compliant batch production" for small-to-medium-sized enterprises.
Core Performance: Three Major Systems Address Industry Pain Points
1. Filling System: High Precision + Low Loss + Strong Compliance
• Imported stainless steel plungers with mirror-finish polishing (Ra ≤ 0.2μm), offering stepless adjustment from 0 to 1.5ml. The measurement error increment is ≤ 0.1% after 800 hours of continuous operation, eliminating precision drift across multiple batches.
• Siemens servo closed-loop control (response time ≤ 50ms) automatically accommodates ±15% fluctuations in material viscosity, ensuring dosage consistency.
• Integrated 316L stainless steel hopper + sanitary quick-connect piping, with single-batch residue ≤ 0.3g. It incorporates CIP (Clean-in-Place) online cleaning functionality, meeting GMP compliance requirements.
2. Transmission System: High Stability + Low Noise + Cost Savings
• 40CrNiMo alloy main shaft paired with SKF high-precision bearings, achieving radial runout ≤ 0.02mm and capsule size consistency ≥ 99.5%.
• Helical cylindrical gear transmission with operating noise ≤ 65 dB(A). The mold service life exceeds 1000 batches, reducing spare parts replacement costs by 40%.
Precision temperature control system (temperature accuracy ±0.3℃) with 3 preset exclusive curves for colloid materials, seamlessly adapting to animal gelatin, plant-based colloids, and other substrates.
3. Process Adaptation System: Flexibility + High Compatibility + Strict Compliance
• Exclusive brass glue tank featuring high thermal conductivity and corrosion resistance. Combined with double-layer temperature control for the spreading chamber (upper layer 50-70℃ ±0.5℃, lower layer 20-30℃ ±1℃), it achieves a global temperature difference of ≤ 0.3℃ for glue liquid. This resolves the forming challenge of high-viscosity materials (≥5000 mPa·s), with film thickness adjustment precision reaching 0.01mm.
• SUS304 stainless steel outer cover (R3 arc transitions at joints) + 316L detachable contact components, complying with GMP Appendix 1 and FDA 21 CFR Part 11 standards to enable one-time audit pass.
Integrated φ300×500mm stainless steel drying drum, supporting temperature control of 35-60℃ (±1℃) and humidity adjustment of 30%-60%RH. It enables closed-loop drying of capsules within 10 seconds of forming, reducing contamination risk by 90% and keeping the coefficient of variation for disintegration time ≤ 3%.
Core Technical Parameters
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Key Indicators
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Technical Parameters
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Core Application Value
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Capacity Range
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15,840 capsules/hour (#0 Oval, 500mg);
8,160 capsules/hour (20# Oblong, 1000mg)
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Adapts to 500-capsule pilot-scale testing to 50,000-capsule batch production, enabling seamless alignment of R&D data with production parameters
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Filling Precision
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±0.5% (500mg); ±0.8% (1000mg)
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Ensures data repeatability (RSD ≤ 2%), stabilizes drug efficacy, and reduces R&D trial-and-error costs
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Mold Roller Specification
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φ80×100mm (4″), aviation-grade aluminum (HRC 32-35)
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Lightweight design (30% lighter than traditional molds), extending service life and lowering maintenance costs
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Temperature Control Range
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Mold roller 5-25℃ (±0.3℃); Spreading chamber 50-70℃ (±0.5℃); Drying drum 35-60℃ (±1℃)
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Precise temperature control throughout the entire process, adapting to multi-material production and reducing process commissioning complexity
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MTBF (Mean Time Between Failures)
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≥5000 hours
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Supports 72 hours of continuous operation with equipment utilization rate ≥95%, minimizing downtime losses
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Power Consumption
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5kw (1.2kw in standby)
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20% more energy-efficient than similar equipment, saving over 2,400 kWh of electricity annually and reducing operating costs
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Brass Glue Tank Characteristics
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High thermal conductivity and corrosion resistance; glue liquid temperature difference ≤0.3℃
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Expands the compatibility range for high-viscosity materials and improves film forming qualification rates
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Drying Drum Parameters
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φ300×500mm, rotation speed 5-20RPM, humidity 30%-60%RH
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Eliminates contamination from manual transfer, improves drying uniformity by 40%, and reduces annual rework loss costs by 100,000-200,000 yuan
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Product Value
The JL-100II breaks the industry misconception that "small equipment = low precision + low stability," achieving efficient integration of "laboratory-grade precision" and "industrial-scale stability." For R&D institutions, it reduces high-value material loss and shortens formula verification cycles. For small-to-medium-sized pharmaceutical enterprises, it meets compliant production requirements without heavy investment, catering to niche tracks such as orphan drugs and plant-based capsules.
Against the backdrop of rapid development in precision medicine and green formulations, the JL-100II – as a core equipment deeply rooted in the niche market – helps upgrade small-batch production toward "precision, compliance, and low cost," accelerating the commercialization of laboratory innovative technologies into market-ready products.
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